Wilson County, in the south central part of Texas, was organized by an act of the legislature of the State of Texas on February 13, 1860 from Karnes and Bexar counties. The county is named after James Charles Wilson, an early settler of Texas and later a state legislator.

The area that now comprises Wilson County has been the site of human habitation for several millennia. Archeological evidence reveals that hunter-gatherer Indians of the Coahuiltecan linguistic family occupied the region for several thousand years prior to the arrival of Europeans in the sixteenth century. The area was also in the hunting range of Comanche, Tonkawa, and Lipan-Apache Indians.

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